Introducing Calyphi
Calyphi builds open, browser-first tools for researchers. Rigorous statistics, zero data collection, no subscriptions. Start with CurveFit — more instruments coming soon.

Scientific curve fitting — instant, accurate, private.
GraphPad Prism costs €520 /year. Origin, SigmaPlot, and MATLAB carry similar price tags. For researchers who just need to fit a curve — especially in labs with tight budgets — that's hard to justify.
Meanwhile, free alternatives are either too basic (no model selection, no error estimation) or too complex (scripting in R or Python for every dataset).
Calyphi CurveFit gives you publication-ready fitting in seconds — for free, with no sign-up, and with complete data privacy.
From linear to Hill, Michaelis-Menten, sigmoidal, power-law, and custom equations.
Gold-standard nonlinear regression with multi-start to avoid local minima.
Akaike weights rank every model — no guessing which curve fits best.
≈95 % CI on parameters and prediction bands on the curve, automatically.
Runs entirely in your browser. Zero data ever leaves your device.
Paste data, click fit, done. No install, no account, no waiting.
No account. No install. Paste your data and get results in seconds.
Open CurveFit — FreeLevenberg–Marquardt optimization · AICc model selection · Akaike weights · Delta-method confidence intervals · Multi-start global search